Kelly Monaco is leaving “General Hospital” after 21 years

Monaco's Sam McCall will exit the ABC soap this fall.

Sam McCall is on her way out of Port Charles.

Actress Kelly Monaco, who has portrayed the character of Samantha McCall on ABC's General Hospital since 2003, is leaving the show, Entertainment Weekly has confirmed.

The Soap Opera Network first reported the news on Monday. Reps for the actress did not immediately respond to EW's request for comment.

Related: Murder charges announced in fatal shooting of General Hospital actor Johnny Wactor

After nearly 2,300 episodes, Monaco will make her final appearance this fall. The Soap Opera Network reported that McCall will be "killed off" the show.

Over her 21 years on the soap, Monaco's has been nominated for a daytime Emmy and other accolades. She previously had been recognized for her 300-plus episodes on Port Charles.

Outside of her work on GH, Monaco is perhaps best known for winning Dancing With the Stars in its first season in 2005.

Related: Emma Samms is checking back in for more General Hospital

Just as Monaco is departing the long-running daytime TV series, several other actors with a history there have returned.

This summer, Jonathan Jackson, who first played Lucky Spencer back in 1993, returned for the first time since 2015. Emma Samms, who's portrayed Holly Sutton on and off since 1982, including once when she seemed to come back from the dead, is scheduled to be back in September. Actor Rick Hearst also reprised his role of Ric Lansing, the half-brother of mob boss Sonny Corinthos, just this month.

The show launched in 1963 and holds the Guinness World Record for the longest-running American soap opera in production.

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