Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More
Getting a prescription for tadalafil (the active ingredient in brand names Adcirca and Cialis) can be a more complicated experience than many men expect. While Cialis and its generic tadalafil are effective ED treatments, many men get overwhelmed by the dosages and ways to take the medication.
Like sildenafil (the active ingredient in Viagra), avanafil (sold as Stendra) and other ED medications, tadalafil is available in several dosages, but unlike the others, it can also be prescribed for daily use.
While the maximum dose of tadalafil for ED may give you intense arousal, it’s important to choose the right dosage for your individual needs to experience minimal side effects and avoid permanent or serious injury. Here’s what to know if you want the best results possible.
How Tadalafil Dosing Works
Since tadalafil is the longest-lasting medication for ED, you have to treat it differently than many other medications on the market. The key reason: A single dose of tadalafil may provide relief from ED for up to 36 hours — about one and a half days.
If we wade into the science for a moment, that means the half-life of tadalafil is approximately 17.5 hours. That’s a really long time — and it’s only an average. In elderly men, for instance, tadalafil has a slightly longer half-life of roughly 21.6 hours.
As a long-lasting ED medication, tadalafil is only recommended for use one time per day. When used at a typical as-needed dosage, tadalafil remains effective for up to 36 hours.
For optimal results, it’s recommended to take tadalafil at least 30 minutes before you and your partner plan to have intercourse. But if you are intimate every four hours (high-five to that), you won’t want to use tadalafil every time — this could be very dangerous.
Tadalafil Dose Uses
Contrary to popular belief, tadalafil and other PDE5 inhibitors won’t make you get random arousal. Instead, proper use of tadalafil just increases blood flow to your member, meaning you’ll only get aroused when you receive stimulation.
Tadalafil works by inhibiting the effects of cGMP-specific phosphodiesterase type 5 (or PDE5) — an enzyme found in the smooth muscle cells of blood vessels. PDE5 plays a major role in regulating the flow of blood to certain parts of your body, including the arousal tissues of your member. By inhibiting the effects of PDE5, tadalafil makes it easier for blood to flow "downstairs" and for you to get hard.
This guide to PDE5 inhibitors has more information about how tadalafil, sildenafil and other medications for ED work. There are a number of common use cases for this medication, including:
Daily tadalafil for ED
On-demand tadalafil for ED
Tadalafil for the symptoms of benign prostatic hyperplasia (BPH)
Tadalafil for pulmonary arterial hypertension (PAH)
Let’s look at the actual dosages in more detail.
Tadalafil Dose and Timing Guide
The prescription drug is a PDE5 inhibitor, meaning it blocks phosphodiesterase type 5 enzymes that reduce blood flow to the penile tissues. So tadalafil essentially treats ED by increasing blood flow to your member, making it easier for you to get hard when you feel aroused.
Tadalafil is available in several dosages, from a minimum dosage of 2.5mg (milligrams) all the way up to a 20mg per tablet, the maximum dose of tadalafil in 24 hours.
Tadalafil 10mg: Typical Starting Dose
10mg is the typical starting dosage of as-needed tadalafil. The medication is typically prescribed at this dosage for use as needed before intercourse for men with mild to moderate ED. And if you begin your ED treatment journey with tadalafil, you’ll almost certainly be prescribed a 10mg dose to start.
Research shows that most men with ED who use tadalafil at this dosage are able to have intercourse successfully. Still, it’s possible that this dosage won’t meet your individual needs. In this case, your healthcare provider may prescribe a higher dose. For all as-needed dosages, you’ll typically want to take tadalafil at least 30 minutes to two hours before you plan to get intimate.
Mild ED Dose: 5mg Tadalafil
If your ED is fairly mild, or if you develop side effects from using tadalafil at a higher dosage, your healthcare provider may prescribe tadalafil at a dosage of 5mg.
This is the lowest as-needed tadalafil dosage currently available. Although it’s slightly less effective than the 10mg and 20mg dosages at treating ED, it’s also less likely to cause certain side effects — which, for men with heart conditions and those vulnerable to dizziness, can be a necessary precaution for safe and effective use.
Tadalafil 20mg: Max Dose
If you don’t notice any improvements from a 10mg dosage, or don’t experience a big enough improvement to have satisfactory intercourse, your healthcare provider may prescribe a stronger 20mg dosage of tadalafil.
The maximum dosage of tadalafil is 20mg, used as needed for intercourse for men with more severe ED. If you’re prescribed tadalafil at this dosage, it’s likely because smaller doses weren’t giving you the results you were hoping for. Since tadalafil 20mg dosage is a higher dose, it’s important to follow your healthcare provider’s instructions and take your medication no more than once per day.
At this dosage, tadalafil is more effective at improving ED and helping men with ED have intercourse successfully. Research shows that a dosage of 20mg is particularly effective for men with severe ED. Clinical trials show that side effects from tadalafil are slightly more common at this dosage than at a lower dosage of 10mg, though the difference in tolerability is relatively small.
For Daily Tadalafil Dosing: 2.5mg and 5mg Tadalafil
While tadalafil is available as-needed, it’s also available for once-daily use in much smaller dosages for always-on preparedness for intimate activity. Daily dose tadalafil is available at a dosage of 2.5mg or 5mg tablets.
There might be several reasons to go with daily dosages instead of the dosages where you take the medication as needed. Using tadalafil daily offers several advantages, as explained in this full guide to daily-use Cialis.
However, keep in mind that daily use might change the side effect outcomes for some people. Side effects such as indigestion and flushing may become more frequent with daily use. When used daily, tadalafil should be taken at approximately the same time each day to maintain a stable concentration in the body.
Tadalafil Dosage Side Effects
It’s important to know that side effects can increase based on dosage, frequency of use and whether you’re on any other medications.
This comprehensive guide covers the numerous (and mostly tolerable) tadalafil side effects, but serious side effects at all dosages can include:
Hearing loss
Loss of vision
Priapism (prolonged arousal without stimulation)
Once you and your healthcare provider work out the correct dosage for you, tadalafil should effectively improve your arousal and enhance your performance in the bedroom.
But there are also some potentially dangerous mistakes you’ll want to avoid when taking tadalafil — let’s look at those in the big picture of how to take the medication correctly.
Tadalafil Drug Interactions
Drug interactions can be serious business. If you’re taking certain medications, you might need a lower dose of tadalafil, so tell your healthcare provider if you use:
Alpha blockers
Nitrates, nitroglycerin and nitric oxide supplements
Ketoconazole, itraconazole or other antifungal medications
Tamsulosin
Erythromycin
Doxazosin
You should also tell your healthcare provider if you have renal or kidney disease, angina, Peyronie’s disease, an enlarged prostate or pulmonary hypertension (high blood pressure). You’ll want to avoid consuming grapefruit juice while taking tadalafil; the juice can lead to some of the same interactions as those of prescription drugs.
How to Take Tadalafil Dose for Best Results
Not following best practices around tadalafil can reduce the medication’s effectiveness, increase your risk of common side effects and generally make your tadalafil-taking experience less optimal. You don’t want to do any of those things intentionally. Instead, follow this guide. To get the best results from tadalafil, try to:
Take tadalafil at least 30 minutes before intercourse. Tadalafil usually reaches its peak blood concentration between 30 minutes and six hours. If you’re prescribed tadalafil for use as needed, you’ll get the best results by taking it at least 30 minutes before you and your partner plan to be intimate. If you don’t notice any improvement, try taking tadalafil about two hours before intercourse.
Limit your alcohol consumption. Taking tadalafil (Cialis) with alcohol may increase your risk of developing side effects, including reduced blood pressure. Alcohol can also affect your performance and ability to maintain arousal during intercourse. It’s okay to drink a small amount of alcohol while using tadalafil, but it’s best to avoid heavy drinking while using this medication.
Combine tadalafil with a healthy lifestyle. Your cardiovascular health plays a key role in your ED and performance, meaning medications such as tadalafil work best if you live a healthy lifestyle.
Avoid drug interactions. Medications and foods may cause problems with ED medication and intensify the effects of tadalafil. Beyond potential drug interactions, this also means that you shouldn’t double up on a missed dose.
Obviously, there are many things you can do to take tadalafil incorrectly, and the worst of them is, arguably, taking too much of the medication. For example, taking 40mg of tadalafil (two 20mg tablets) is not recommended when being used for ED. This dosage of tadalafil is higher than the typical recommended dose for ED and could increase your risk of developing side effects, including potentially harmful side effects.
Do not double your dose without professional supervision. And if you don’t experience improvements from tadalafil at a dosage of 10mg or 20mg, talk to your healthcare provider. They’ll be able to guide you through other steps so you can have a happy and healthy bedroom life.
Tadalafil Dosages for ED: Final Thoughts
If you’re one of the tens of millions of men in the United States affected by ED, medications like tadalafil can improve your arousal and make it easier to have satisfying intercourse.
But you have to take it properly and safely to get the results you want. The following cheat sheet will help you get what you need safely — and get your bedroom game back in action:
Tadalafil is one of four FDA-approved oral medications for ED, along with sildenafil (Viagra), vardenafil (Levitra) and avanafil (Stendra).
Tadalafil is a widely used medication, mostly prescribed to treat ED and sometimes to treat the symptoms of benign prostatic hyperplasia (BPH) as well as pulmonary arterial hypertension (under the brand name Adcirca).
Compared to other ED medications, tadalafil is very long-lasting. On average, a typical 10mg dose of tadalafil can improve arousal function for up to 36 hours.
Tadalafil is available in several dosages. As a treatment for ED, it’s typically prescribed at a dosage of 10mg for use as needed, which may be adjusted to 20mg or 5mg based on your response to the medication.
For once-daily use, tadalafil is prescribed at a lower dosage of either 2.5mg or 5mg per day.
As with other ED medications, there’s no “best” dosage of tadalafil for all. Your healthcare provider will work with you to choose the best dosage based on your desired health outcomes, including treatment for benign prostatic hyperplasia.
You should be taking tadalafil or any ED medication only as directed with medical advice, which means no double-dosing without the approval of a healthcare professional.
If medication isn’t helping, there’s more you can do. This guide to naturally protecting your arousal shares actionable, science-based tactics you can use to improve your intimacy health and get better results from tadalafil.
You can learn more about the treatment of ED and improving your performance in this guide to the most common ED treatments and drugs.
This article originally appeared on Hims.com and was syndicated by MediaFeed.org.
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8 Foods that Help Men with ED
Whether we’re craving salt, sugar, a cold beer or a perfectly cooked steak, every guy knows how to satisfy his own cravings.
Here’s the thing though: if you’re having some problems in the bedroom, you might want to satisfy someone else’s cravings and nutritional needs.
These days when ED pops up (or rather, doesn’t pop up), doctors and knowing friends name-drop a certain little blue pill as the quickest pathway to righting the ship.
But, making changes to your habits, lifestyle and diet can also improve your performance and make it easier to get and stay aroused.
Yes, foods might be able to help play a role in managing ED — they potentially do so by improving cardiovascular health, increasing blood flow and supporting your body’s production of essential hormones.
It’s impressive that by making dietary shifts, you can make yourself healthier and stronger and maybe your arousals as well.
Below, we’ve outlined how foods do it, which foods to eat and some ways to address ED once you’re done with your meal.
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Before we get into the specifics of using food to treat ED, it’s important to put the soon-to-come advice in context. We’ll skip the lecture on how arousal work — you figured that out on your own.
Instead, we’ll start with our first ED fact — that ED can vary in severity. Most of us might assume that it’s either up or down, but ED is more nuanced than that.
Some men experience mild ED — they can mostly get hard, but occasionally struggle to get all the way hard. Others have such severe ED that they’re unable to get any arousals, at any time.
Food is important for overall health and might help both types of men and those in-between, but will likely have the most effect for men at the milder end of the spectrum.
If you have mild to moderate ED, making changes to your diet and lifestyle can be an important part of making it easier for you to get aroused.
If you have severe or persistent ED meanwhile, it’s best to think of diet as one aspect of management on a list of several useful ones.
Either way, it’s important to talk to a healthcare provider to discuss the best holistic plan to address your ED. In some cases, dietary changes only have an effect in the long term — meaning you need to shift your diet long-term in order to see a potential benefit (you can’t just eat a food and expect it to correct your ED an hour later). In other cases, diet may only help if you have an actual vitamin or mineral deficiency that’s contributing to your ED, which can be rare.
We’ve talked more about the other options (including medications for ED) in our full guide to ED symptoms, causes and treatments.
But you can look at that later. For now, let’s take a peek at your pantry.
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The reason the following foods might be helpful isn't because they're delicious or hot (you wouldn’t say that about protein powder, for instance), but because they contribute to overall cardiovascular health or contain supplies of the critical building blocks our bodies need to produce a healthy arousal.
Another great thing about these foods is that you may already have some in your kitchen right now. Many of the foods that have arousal benefits are staples, so you won't need to find obscure ingredients or look up "tiger nuts benefits arousal".
Some may help with blood flow, others may support your testosterone production, but the following foods might all play a role in helping your arousal if you’re willing to incorporate them into your diet:
Spinach, lettuce and other nitrate-rich vegetables
Oysters and other shellfish
Proteins like meat, dairy and nuts
Cocoa, chocolate and other flavonoids
Tomatoes, watermelon and other sources of lycopene
Avocados
Coffee
The foods of the Mediterranean diet
Now let’s look at why these foods are what your arousal might be craving.
(Related: The 5 Best Drinks for ED)
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Your privates aren't Popeye, but guzzling spinach might have a similar effect on your arousal that it always had on his muscles before saving Olive Oyl.
That’s because spinach, lettuce and similar vegetables are rich in nitrates, natural chemical compounds that have a vasodilating effect.
Nitrates affect a process called the nitrate‐nitrite‐nitric oxide pathway, in which nitrates are recycled in blood and tissue to produce nitric oxide — an important molecule for your vascular health and blood flow.
And most vegetables (especially the green leafy ones) contain nitrates. Research published in PLOS shows that green, leafy vegetables such as parsley, spinach and beet leaves tend to have the highest concentration of nitrates, while root vegetables and fruiting vegetables (like bell peppers) contain lower amounts.
By the way, these leafy greens are also high in folic acid, and folic acid deficiency may be associated with ED severity.
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Oysters are considered an aphrodisiac, but they’re associated with arousal for more than the familiar slurping noises.
Your favorite blue points and other shellfish are actually rich in zinc — an essential mineral linked to testosterone levels.
As the primary male hormone, testosterone plays a key role in your functioning. When a man’s testosterone levels are low, he may feel less interested in arousal and experience issues like ED.
Zinc supplementation may play a role in increasing testosterone levels in men who are deficient, meaning it could help you get hard if a zinc deficiency is hindering your testosterone production.
Zinc can be found in a wide variety of foods, including:
Crab
Lobster
Beef
Pork
Beans
Chicken
Fortified breakfast cereals
Chickpeas
Pumpkin seeds
And zinc is also commonly available as a supplement. Oysters just contain by far the highest levels of zinc of any common food — and are the best source to consume over cocktails.
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Protein will help you get swole, but sources of protein are also sources of L-arginine — a common amino acid that may help your privates get swole too.
L-arginine is used to create nitric oxide (we already mentioned how that’s important). But research has noted that men with ED often have low levels of L-arginine too.
A 2003 study found that a combination of L-arginine and pycnogenol (a type of bark from the Pinus pinaster tree) helped men affected by ED regain normal performance over the course of several months.
L-arginine is found in:
Red meat
Poultry like chicken or turkey
Seafood like salmon (which gets bonus points for its omega-3 fatty acids)
Dairy like milk or cottage cheese.
Nuts like pistachios, almonds and walnuts
Protein powders and other supplements for athletic performance and general well-being
(Related: Does Honey Make You Last Longer?)
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Most of us view chocolate as a treat rather than a medicinal food — at best, we may fill up on it during the holidays, and keep a supply on hand for when our partner is moody.
But dark chocolate may offer ED benefits through a compound called a flavonoid, which is a type of naturally-occurring plant chemical with antioxidant effects.
Research published in the American Journal of Clinical Nutrition found that a higher intake of foods rich in flavonoids is associated with a reduced risk of developing ED.
Flavonoids are found in many common foods, including:
Nuts
Tea and tea leaves
Cocoa
Dark chocolate
Whole grains like oats
Fruits like oranges, blueberries, apples and peaches
Vegetables like carrots and chili peppers
Red wine
While eating chocolate in excess obviously isn’t a good idea if you’re trying to keep weight off, eating one or two small pieces of dark chocolate each day is unlikely to hurt and it might help you to maintain healthy blood flow for arousals.
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What do the most popular fruits of stage comedy performances (watermelons and tomatoes) have in common? Aside from making a great mess when thrown, they may also promote boners when consumed.
Tomatoes, watermelon, guavas, papaya and other fruits are all great sources of lycopene — an important plant-based nutrient with antioxidant properties. There may also be benefits guava leaves arousally, which we explore in this guide.
Lycopene is also associated with improved vascular function generally.
While very little research is available on the potential effects of lycopene on performance in humans, some animal research has found that lycopene may play a role in improving health.
One 2012 study found that lycopene restored arousal function in male rats with diabetes and ED, and another animal study found that lycopene may have certain benefits for cardiovascular health — an important component of arousal.
Full disclosure: animal studies don’t always translate for humans.
But the big picture is that many fruits and vegetables are also rich in other nutrients and compounds that may help with ED.
Watermelon, for example, contains the amino acid L-citrulline, which is linked to a variety of vascular health benefits.
In a 2017 scientific review, researchers found that L-citrulline supplementation may increase nitric oxide levels, reduce blood pressure and improve flow to blood vessels.
Learn about another fruit with potential benefits in our blog on the surprising arousal benefits of mangos.
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They may prevent you from achieving home ownership, but avocados are rich in dietary fiber and healthy fats that can contribute to better cardiovascular health and blood flow.
There’s no direct scientific research on avocados and ED specifically, but these effects could be building blocks of improved arousal wellness.
Consider the cholesterol question. Research found that avocados may help lower levels of low-density lipoprotein, or LDL, a form of cholesterol that can clog arteries and affect blood flow.
Avocados also contain a bit of zinc (remember, zinc deficiency associated with ED severity), and small amounts of vitamin E and selenium, both of which are linked to improvements in sperm motility, semen quality and male fertility. Curious to know more about avocado benefits arousally? Check out this guide for more information about this superfood.
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Perking up your sleepy daytime hours might also perk up your privates, sir.
A study published in PLOS One in 2015 analyzed the relationship between coffee drinking and ED by looking at 3,724 men aged 20 and above. These guys were surveyed about their eating and drinking habits and health.
The study found that men who consumed the least caffeine were more likely to report ED than men who consumed the equivalent of two to three cups of coffee per day.
That said, a different study published by the American Journal of Epidemiology in 2018 found no difference in ED risk between men who consumed the highest amount of coffee (four or more cups per day) and the lowest amount (zero cups per day).
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No, it’s not one specific food, but hear us out. The Mediterranean diet consists of fruits and vegetables, grains, nuts and seeds.
It uses olive oil as its source of fat, and includes protein sources such as fish, poultry, dairy products and eggs in low to moderate amounts. In other words, it combines a lot of the stuff we’ve already mentioned, plus much more.
A 2017 review in the Central European Journal of Urology found that adherence to a Mediterranean diet may reduce the risk of developing ED, specifically by improving metabolism, increasing antioxidants, and raising arousal-promoting arginine levels.
The Mediterranean diet also emphasizes limiting simple sugars, salt, refined carbohydrates, saturated fats and heavily processed or fatty meats — things you should moderate anyway for your well-being.
And it even includes ingredients like turmeric, olive oil and lemon juice, which might also benefit your general well-being.
So maybe whip up a little salmon and a fresh salad dressing to go along with those oysters? It’s your kitchen, not ours, but by now you should understand what the best choices are.
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Eating a handful of the wrong snack isn’t going to make your penis fall off (unless that snack is leprosy-flavored goldfish or something) but we have to admit that a pattern of unhealthy eating can contribute to various circulatory and metabolic syndromes that may lead to ED.
For your health, you should avoid, limit or moderate saturated fats, sugar, alcohol and a few other things.
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You probably have no idea what makes a fat saturated, and that’s fine, because most people don’t.
Saturated fats are fats that are solid at room temperature, like lard, dairy and other animal-based products. They can lead to higher levels of “bad” (artery-clogging) cholesterol in the blood.
Consuming saturated animal fats and trans fats in excess can negatively impact your heart by contributing to atherosclerosis, according to the U.S. National Library of Medicine.
Atherosclerosis is a condition in which fatty deposits accumulate along artery walls, causing the arteries to narrow and increasing the risk for heart attack and stroke.
If your arteries are clogged, reduced circulation could not only affect your heart but also your ability to achieve and maintain arousal.
You should also avoid fatty foods when taking Viagra, but that’s another story.
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Sorry to tell you this, but a sweet tooth can eventually lead to a soft penis. According to the Scientific Advisory Committee on Nutrition (SACN), over-consumption of sugar-sweetened beverages and other sugary foods is linked to weight gain and an increase in body mass index.
Obesity is directly linked to arousal issues, which makes sugar an indirect contributing factor for these same problems.
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In addition to foods, you’ve gotta keep your eye on your drinking, man. Excessive alcohol consumption can inhibit blood flow, reduce sensation and revoke your arousal privileges for the evening.
One study by the Indian Journal of Psychiatry showed that 72 percent of men who are dependent on alcohol had one or more dysfunction disorders, including PE, low arousal desire or ED.
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You are what you eat, but your arousal is what you eat, drink (we're looking at you, energy drinks), smoke and do with your life. So eat better, but also do better at taking care of your arousal.
Although making changes to your diet and lifestyle can improve your performance and make ED less severe, the most effective way to treat ED is through the use of medication with clinically proven ingredients. Common oral ED treatments include:
Sildenafil. The active ingredient in Viagra, sildenafil (generic Viagra) provides relief from ED for around four hours.
Tadalafil. The active ingredient in Cialis, tadalafil is a long-lasting medication that can provide relief from ED for up to 36 hours.
Vardenafil. The active ingredient in Levitra, vardenafil can provide relief from ED for slightly longer than sildenafil.
Avanafil. Sold as Stendra, avanafil is a newer ED medication that’s fast-acting and less likely to cause certain side effects than older medications.
These medications can be found in pill, tablet or mint form, if you’re interested in chewable ED meds.
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Since arousal health is so closely linked to your general health, maintaining good habits and a healthy lifestyle can often help to improve your performance.
Try the following changes to habits and lifestyle factors to improve your performance and reduce your risk of ED:
Maintain a healthy weight. Obesity and ED are closely linked with each other — in fact, research shows that having a body mass index (BMI) in the obese range triples your risk of ED. To reduce your risk of dealing with ED, try to maintain a healthy body weight. Although BMI is far from ideal, the CDC says that aiming for a BMI in the healthy range is a good way to limit your risk of developing health issues.
Exercise regularly. Research shows that aerobic exercise is linked to improvements in performance. A review of five studies published in the Ethiopian Journal of Health Science found that men with ED who engage in regular physical activity experience significant improvements in health.
If you smoke, try to quit. Research published in Andrologia shows that smoking is a major risk factor for ED, with the amount of tobacco you smoke closely correlated with your risk of developing ED and cardiovascular disease. If you smoke, make an effort to quit.
Making other changes to your lifestyle, such as reducing stress and treating underlying medical issues such as high blood pressure or heart disease, can also have a positive impact on your health and performance.
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Picking the best foods for your arousal life is about more than avoiding foods that give you bad gas in the night — it’s about a healthy diet.
Leafy greens, dark chocolate and a dozen half shells are a good start, but you’ve got to look at the big picture for stronger arousals (and not the dessert menu). You can also read up on how other foods affect your life too, such as the benefits of pineapple.
Remember, ED is one of the most common men’s health issues out there. According to the National Institute of Diabetes and Digestive and Kidney Diseases, an estimated 30 million men in the United States are affected by some level of ED.
If you want to help manage with diet, keep the following in mind:
YES, adding certain foods to your diet may help to improve your heart health, promote optimal blood flow and make it easier to get aroused.
AND over the long term, improving your diet and habits can also have a huge positive impact on your life. It can also help certain health conditions like ED due to obesity, too little exercise, or another physical health issue.
HOWEVER, it’s important to put the effects of an arousal-friendly diet in context. Eating more spinach is generally a good thing for your health, but improving your diet won’t cause your ED to immediately disappear. Similarly, there may be some celery benefits arousally but the research is iffy.
SO, you may need more help. Currently, the most effective way to treat ED is through the use of medications like sildenafil (the active ingredient in Viagra) and others.
This article originally appeared on Hims.com and was syndicated by MediaFeed.org.
